This is useful as it can conserve ammunition. If a heavy shielded enemy is approaching, one player should act as bait while the other goes round the back to shoot. It is a good idea to use the knife in front of windows as you will have protection because you will be unreachable through it (Watch out for enemies who will jump out behind you though). This is only useful if either player is short on ammo. When on co-op, time it so that you are swiping alternately so when one has just swiped the air and is recovering, the other will be attacking. This is most likely with Sheva's Roundhouse kick. If Attack Reaction is turned on, some melee moves may knock down your partner. If an enemy is on their knees, go behind them and you will get the opportunity for a Neck Breaker (Chris) or Throat Slit (Sheva).

Also, when doing an uppercut, try and work out the path your fist will follow, try to line it up with their head and it will once again destroy their head. When an enemy is on the floor, position your character behind the enemy's head so you are facing down its body, if you do it right the stomp should destroy the head completely - an instant kill unless a Plagas spawns. Melee attacks can be triggered by hitting a majini in the head, arms or legs. Characters are invincible while performing melee attacks.

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